MicroRNA Regulation of Gene Expression

Dr Ania Wilczynska

Investigator Scientist

MRC Toxicology Unit
Hodgkin Building
PO Box 138
University of Leicester
Lancaster Road, Leicester
LE1 9HN, UK

Tel: +44 (0)116 252 5590
Email: Send Email

Research Interests

miRNP particles in translational repression and the cell cycle. Relations between different mechanisms of translational control – particularly miRNA-mediated repression.

Publications List

Meijer HA, Kong YW, Lu WT, Wilczynska A, Spriggs RV, Robinson SW, Godfrey JD, Willis AE, Bushell M.  Translational repression and eIF2A2 activity are critical for microRNA-mediated gene regulation.  Science, 2013 5 April: Vol. 340 no. 6128 pp. 82-85 DOI: 10.1126/science.1231197

Charlesworth A, Yamamoto TM, Cook JM, Silva KD, Kotter CV, Carter GS, Holt JW, Lavender HF, MacNicol AM, Ying Wang Y, Wilczynska A. Xenopus laevis zygote arrest 2 (zar2) encodes a zinc finger RNA-binding protein that binds to the translational control sequence in the maternal Wee1 mRNA and regulates translation. Dev Biol. 2012 Sep 15;369(2):177-90.

Minshall N, Allison R, Marnef A, Wilczynska A, Standart N. Translational control assessed using the tethered function assay in Xenopus oocytes. Methods. 2010 May;51(1):165-9. Epub 2010 Feb 25. Review. PubMed PMID: 20188836.

Armisen J, Gilchrist MJ, Wilczynska A, Standart N, Miska EA. Abundant and dynamically expressed miRNAs, piRNAs, and other small RNAs in the vertebrate Xenopus tropicalis. Genome Res. 2009 Oct;19(10):1766-75. Epub 2009 Jul 23. PubMed PMID: 19628731; PubMed Central PMCID: PMC2765267.

Wilczynska A, Minshall N, Armisen J, Miska EA, Standart N. Two Piwi proteins, Xiwi and Xili, are expressed in the Xenopus female germline. RNA. 2009 Feb;15(2):337-45. PubMed PMID: 19144913; PubMed Central PMCID: PMC2648701.

Ernoult-Lange M, Wilczynska A, Harper M, Aigueperse C, Dautry F, Kress M, Weil D. Nucleocytoplasmic traffic of CPEB1 and accumulation in Crm1 nucleolar bodies. Mol Biol Cell. 2009 Jan;20(1):176-87. Epub 2008 Oct 15. PubMed PMID: 18923137; PubMed Central PMCID: PMC2613105.

Mollet S, Cougot N, Wilczynska A, Dautry F, Kress M, Bertrand E, Weil D. Translationally repressed mRNA transiently cycles through stress granules during  stress. Mol Biol Cell. 2008 Oct;19(10):4469-79. Epub 2008 Jul 16. PubMed PMID: 18632980; PubMed Central PMCID: PMC2555929.

MacNicol AM, Wilczynska A, MacNicol MC. Function and regulation of the mammalian Musashi mRNA translational regulator. Biochem Soc Trans. 2008 Jun;36(Pt3):528-30. PubMed PMID: 18481998; PubMed Central PMCID: PMC2562719.

Sarnowska E, Grzybowska EA, Sobczak K, Konopinski R, Wilczynska A, Szwarc M, Sarnowski TJ, Krzyzosiak WJ, Siedlecki JA. Hairpin structure within the 3'UTR of DNA polymerase beta mRNA acts as a post-transcriptional regulatory element and interacts with Hax-1. Nucleic Acids Res. 2007;35(16):5499-510. Epub 2007 Aug 17. PubMed PMID: 17704138; PubMed Central PMCID: PMC2018635.

Charlesworth A, Wilczynska A, Thampi P, Cox LL, MacNicol AM. Musashi regulates the temporal order of mRNA translation during Xenopus oocyte maturation. EMBO J. 2006 Jun 21;25(12):2792-801. Epub 2006 Jun 8. PubMed PMID: 16763568; PubMed Central PMCID: PMC1500856.

Grzybowska EA, Sarnowska E, Konopiński R, Wilczyńska A, Sarnowski TJ, Siedlecki JA. Identification and expression analysis of alternative splice variants of the rat Hax-1 gene. Gene. 2006 Apr 12;371(1):84-92. Epub 2006 Mar 3. PubMed PMID: 16516414.

Wilczynska A, Aigueperse C, Kress M, Dautry F, Weil D. The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules. J Cell Sci. 2005 Mar 1;118(Pt 5):981-92. PubMed PMID: 15731006.

Nowak R, Grzybowska EA, Wilczyńska A, Pykało R, Siedlecki JA. Low expression of DNA polymerase beta in human testicular germ cell tumours--impact on foetal gonocytic origin theory. Acta Oncol. 2002;41(2):188-91. PubMed PMID: 12102165.

Grzybowska EA, Wilczynska A, Siedlecki JA. Regulatory functions of 3'UTRs. Biochem Biophys Res Commun. 2001 Oct 26;288(2):291-5. Review. PubMed PMID: 11606041.