2013 Publications

Names of programme leaders at MRC Toxicology Unit appear in bold.

A perspective on mammalian upstream open reading frame function.

Somers J, Pöyry T, Willis AE.

Int J Biochem Cell Biol. 2013 Apr 25. doi:pii: S1357-2725(13)00125-8. 10.1016/j.biocel.2013.04.020. [Epub ahead of print]

Translational repression and eIF4A2 activity are critical for microRNA-mediated gene regulation.

Meijer HA, Kong YW, Lu WT, Wilczynska A, Spriggs RV, Robinson SW, Godfrey JD, Willis AE, Bushell M.

Science. 2013 Apr 5;340(6128):82-5. doi: 10.1126/science.1231197.

Active regulator of SIRT1 is required for ribosome biogenesis and function.

Knight JR, Willis AE, Milner J.

Nucleic Acids Res. 2013 Apr 1;41(7):4185-97. doi: 10.1093/nar/gkt129. Epub 2013 Mar 5.

A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers.

Simpson KL, Cawthorne C, Zhou C, Hodgkinson CL, Walker MJ, Trapani F, Kadirvel M, Brown G, Dawson MJ, Macfarlane M, Williams KJ, Whetton AD, Dive C.

Cell Death Dis. 2013 May 2;4:e613. doi: 10.1038/cddis.2013.137.

Isolation, characterisation and reconstitution of cell death signalling complexes.

Hughes MA, Langlais C, Cain K, Macfarlane M.

Methods. 2013 Feb 26. doi:pii: S1046-2023(13)00025-X. 10.1016/j.ymeth.2013.02.006. [Epub ahead of print]

Sustained tumour eradication after induced caspase-3 activation and synchronous tumour apoptosis requires an intact host immune response.

Melis MH, Simpson KL, Dovedi SJ, Welman A, Macfarlane M, Dive C, Honeychurch J, Illidge TM.

Cell Death Differ. 2013 May;20(5):765-73. doi: 10.1038/cdd.2013.8. Epub 2013 Feb 15.

Insights into mitochondrial quality control pathways and Parkinson's disease.

Lehmann S, Martins LM.

J Mol Med (Berl). 2013 May 4. [Epub ahead of print]

MicroCT Analysis of a Retrieved Root Restored with a Bonded Fiber-Reinforced Composite Dowel: A Pilot Study.

Lorenzoni FC, Bonfante EA, Bonfante G, Martins LM, Witek L, Silva NR.

J Prosthodont. 2013 Apr 1. doi: 10.1111/jopr.12045. [Epub ahead of print]

Oxorhenium Complexes Bearing the Water-Soluble Tris(pyrazol-1-yl)methanesulfonate, 1,3,5-Triaza-7-phosphaadamantane, or Related Ligands, as Catalysts for Baeyer-Villiger Oxidation of Ketones.

Martins LM, Alegria EC, Smoleński P, Kuznetsov ML, Pombeiro AJ.

Inorg Chem. 2013 Apr 15;52(8):4534-46. doi: 10.1021/ic400024r. Epub 2013 Mar 27.

Immunoproteomics and immunoinformatics analysis of Cryptococcus gattii: novel candidate antigens for diagnosis.

Martins LM, de Andrade HM, Vainstein MH, Wanke B, Schrank A, Balaguez CB, dos Santos PR, Santi L, Pires Sda F, da Silva AS, de Castro JA, Brandão RM, do Monte SJ.

Future Microbiol. 2013 Apr;8(4):549-63. doi: 10.2217/fmb.13.22.

Effect of 2% chlorhexidine digluconate on bond strength of a glass-fibre post to root dentine.

Wang L, Pinto TA, Silva LM, Araújo DF, Martins LM, Hannas AR, Pedreira AP, Francisconi PA, Honório HM.

Int Endod J. 2013 Jan 24. doi: 10.1111/iej.12070. [Epub ahead of print]

Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease.

Costa AC, Loh SH, Martins LM.

Cell Death Dis. 2013 Jan 17;4:e467. doi: 10.1038/cddis.2012.205.

Role of p63 and the Notch pathway in cochlea development and sensorineural deafness.

Terrinoni A, Serra V, Bruno E, Strasser A, Valente E, Flores ER, van Bokhoven H, Lu X, Knight RA, Melino G.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7300-5. doi: 10.1073/pnas.1214498110. Epub 2013 Apr 15.

p63 regulates glutaminase 2 expression.

Giacobbe A, Bongiorno-Borbone L, Bernassola F, Terrinoni A, Markert EK, Levine AJ, Feng Z, Agostini M, Zolla L, Agrò AF, Notterman DA, Melino G, Peschiaroli A.

Cell Cycle. 2013 May 1;12(9):1395-405. doi: 10.4161/cc.24478. Epub 2013 Apr 10.

Analysis of the oligomeric state and transactivation potential of TAp73α

Luh LM, Kehrloesser S, Deutsch GB, Gebel J, Coutandin D, Schäfer B, Agostini M, Melino G, Dötsch V.

Cell Death Differ. 2013 Mar 29. doi: 10.1038/cdd.2013.23. [Epub ahead of print]

Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes.

Tucci P, Porta G, Agostini M, Dinsdale D, Iavicoli I, Cain K, Finazzi-Agró A, Melino G, Willis A.

Cell Death Dis. 2013 Mar 21;4:e549. doi: 10.1038/cddis.2013.76.

Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB.

Aksenova V, Turoverova L, Khotin M, Magnusson KE, Tulchinsky E, Melino G, Pinaev GP, Barlev N, Tentler D.

Oncotarget. 2013 Feb;4(2):362-72.

PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling.

Harris IS, Blaser H, Moreno J, Treloar AE, Gorrini C, Sasaki M, Mason JM, Knobbe CB, Rufini A, Hallé M, Elia AJ, Wakeham A, Tremblay ML, Melino G, Done S, Mak TW.

Oncogene. 2013 Feb 25. doi: 10.1038/onc.2013.24. [Epub ahead of print]

Senescence and aging: the critical roles of p53.

Rufini A, Tucci P, Celardo I, Melino G.

Oncogene. 2013 Feb 18. doi: 10.1038/onc.2012.640. [Epub ahead of print]

On Rita Levi-Montalcini.

Melino G, Benedetti B, Bazan N.

Mol Neurobiol. 2013 Apr;47(2):443-5. doi: 10.1007/s12035-013-8407-9. No abstract available.

Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy.

Salah Z, Bar-mag T, Kohn Y, Pichiorri F, Palumbo T, Melino G, Aqeilan RI.

Cell Death Dis. 2013 Jan 31;4:e480. doi: 10.1038/cddis.2013.6.

P73 and age-related diseases: is there any link with Parkinson Disease?

Grespi F, Melino G.

Aging (Albany NY). 2012 Dec;4(12):923-31.

MicroRNA-152 and -181a participate in human dermal fibroblasts senescence acting on cell adhesion and remodeling of the extra-cellular matrix.

Mancini M, Saintigny G, Mahé C, Annicchiarico-Petruzzelli M, Melino G, Candi E.

Aging (Albany NY). 2012 Nov;4(11):843-53.

MicroRNA-203 contributes to skin re-epithelialization.

Viticchiè G, Lena AM, Cianfarani F, Odorisio T, Annicchiarico-Petruzzelli M, Melino G, Candi E.

Cell Death Dis. 2012 Nov 29;3:e435. doi: 10.1038/cddis.2012.174.

Identification of NCF2/p67phox as a novel p53 target gene.

Italiano D, Lena AM, Melino G, Candi E.

Cell Cycle. 2012 Dec 15;11(24):4589-96. doi: 10.4161/cc.22853. Epub 2012 Nov 27.

The "Sharp" blade against HIF-mediated metastasis.

Amelio I, Melino G.

Cell Cycle. 2012 Dec 15;11(24):4530-5. doi: 10.4161/cc.22820. Epub 2012 Nov 27.

MIRUMIR: an online tool to test microRNAs as biomarkers to predict survival in cancer using multiple clinical data sets.

Antonov AV, Knight RA, Melino G, Barlev NA, Tsvetkov PO.

Cell Death Differ. 2013 Feb;20(2):367. doi: 10.1038/cdd.2012.137. Epub 2012 Nov 23. No abstract available.

Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor.

Chen YJ, Oldfield S, Butcher AJ, Tobin AB, Saxena K, Gurevich VV, Benovic JL, Henderson G, Kelly E.

J Neurochem. 2013 Jan;124(2):189-99. doi: 10.1111/jnc.12071. Epub 2012 Nov 30.

Sabutoclax (BI97C1) and BI112D1, Putative Inhibitors of MCL-1, Induce Mitochondrial Fragmentation Either Upstream of or Independent of Apoptosis.

Varadarajan S, Butterworth M, Wei J, Pellecchia M, Dinsdale D, Cohen GM.

Neoplasia. 2013 May;15(5):568-78.

Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.

Varadarajan S, Tanaka K, Smalley JL, Bampton ET, Pellecchia M, Dinsdale D, Willars GB, Cohen GM.

PLoS One. 2013;8(2):e56603. doi: 10.1371/journal.pone.0056603. Epub 2013 Feb 15.

Precision medicines for B-cell leukaemias and lymphomas; progress and potential pitfalls.

Dyer MJ, Vogler M, Samuel J, Jayne S, Wagner S, Pritchard C, Macip S.

Br J Haematol. 2013 Mar;160(6):725-33. doi: 10.1111/bjh.12219. Epub 2013 Jan 24.

The detection of chromosomal translocations involving the immunoglobulin loci in B-cell malignancies.

Dyer MJ.

Methods Mol Biol. 2013;971:123-33. doi: 10.1007/978-1-62703-269-8_7.

BCL7A protein expression in normal and malignant lymphoid tissues.

Ramos-Medina R, Montes-Moreno S, Maestre L, Cañamero M, Rodríguez-Pinilla M, Martínez-Torrecuadrada J, Piris MÁ, Majid A, Dyer MJ, Pulford K, Roncador G.

Br J Haematol. 2013 Jan;160(1):106-9. doi: 10.1111/bjh.12080. Epub 2012 Oct 9. No abstract available.

Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity.

Dudek KM, Suter L, Darras VM, Marczylo EL, Gant TW.

Biochem J. 2013 Apr 16. [Epub ahead of print]

2012 Publications

Names of programme leaders at MRC Toxicology Unit appear in bold.

NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1.

Craxton A, Butterworth M, Harper N, Fairall L, Schwabe J, Ciechanover A, Cohen GM.

Cell Death Differ. 2012 Sep;19(9):1424-34. doi: 10.1038/cdd.2012.16. Epub 2012 Feb 24.

A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum.

Varadarajan S, Bampton ET, Smalley JL, Tanaka K, Caves RE, Butterworth M, Wei J, Pellecchia M, Mitcheson J, Gant TW, Dinsdale D, Cohen GM.

Cell Death Differ. 2012 Dec;19(12):1896-907. doi: 10.1038/cdd.2012.108. Epub 2012 Sep 7.

miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration.

Amelio I, Lena AM, Viticchiè G, Shalom-Feuerstein R, Terrinoni A, Dinsdale D, Russo G, Fortunato C, Bonanno E, Spagnoli LG, Aberdam D, Knight RA, Candi E, Melino G.

J Cell Biol. 2012 Oct 15;199(2):347-63. doi: 10.1083/jcb.201203134.

TAp73 depletion accelerates aging through metabolic dysregulation.

Rufini A, Niklison-Chirou MV, Inoue S, Tomasini R, Harris IS, Marino A, Federici M, Dinsdale D, Knight RA, Melino G, Mak TW.

Genes Dev. 2012 Sep 15;26(18):2009-14. doi: 10.1101/gad.197640.112.

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.

Pimenta de Castro I, Costa AC, Lam D, Tufi R, Fedele V, Moisoi N, Dinsdale D, Deas E, Loh SH, Martins LM.

Cell Death Differ. 2012 Aug;19(8):1308-16. doi: 10.1038/cdd.2012.5. Epub 2012 Feb 3.

The Drosophila inner-membrane protein PMI controls cristae biogenesis and mitochondrial diameter.

Macchi M, El Fissi N, Tufi R, Bentobji M, Liévens JC, Martins LM, Royet J, Rival T.

J Cell Sci. 2012 Dec 21. [Epub ahead of print]

Drosophila happyhour modulates JNK-dependent apoptosis.

Lam D, Shah S, de Castro IP, Loh SH, Martins LM.

Cell Death Dis. 2010 Aug 19;1:e66.

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death.

Dickens LS, Boyd RS, Jukes-Jones R, Hughes MA, Robinson GL, Fairall L, Schwabe JW, Cain K, Macfarlane M.

Mol Cell. 2012 Jul 27;47(2):291-305. Epub 2012 Jun 7. 

Glucose--a sweet way to die: metabolic switching modulates tumor cell death.

MacFarlane M, Robinson GL, Cain K.

Cell Cycle. 2012 Nov 1;11(21):3919-25. doi: 10.4161/cc.21804. Epub 2012 Sep 14.

The 'complexities' of life and death: Death receptor signalling platforms.

Dickens LS, Powley IR, Hughes MA, Macfarlane M.

Exp Cell Res. 2012 Jul 1;318(11):1269-77. Epub 2012 Apr 17.

RNA Binding Protein/RNA Element Interactions and the Control of Translation.

Pichon X, Wilson LA, Stoneley M, Bastide A, King HA, Somers J, Willis AE.

Curr Protein Pept Sci. 2012 Jun 1;13(4):294-304.

Removal notice to “translational profiling of multiple myeloma cell lines RPMI8226 and 8226/R5 to discover novel markers of disease and drug resistance” [Toxicology 290 (2011) 116].

Wilson LA, Cobbold LC, Willis AE.

Toxicology. 2012 Dec 16;302(2-3):319. No abstract available

Failure of translation of human adenovirus mRNA in murine cancer cells can be partially overcome by L4-100K expression in vitro and in vivo.

Young AM, Archibald KM, Tookman LA, Pool A, Dudek K, Jones C, Williams SL, Pirlo KJ, Willis AE, Lockley M, McNeish IA.

Mol Ther. 2012 Sep;20(9):1676-88. doi: 10.1038/mt.2012.116. Epub 2012 Jun 26.

microRNAs in cancer management.

Kong YW, Ferland-McCollough D, Jackson TJ, Bushell M.

Lancet Oncol. 2012 Jun;13(6):e249-58.

Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes.

Ferland-McCollough D, Fernandez-Twinn DS, Cannell IG, David H, Warner M, Vaag AA, Bork-Jensen J, Brøns C, Gant TW, Willis AE, Siddle K, Bushell M, Ozanne SE.

Cell Death Differ. 2012 Jun;19(6):1003-12. doi: 10.1038/cdd.2011.183. Epub 2012 Jan 6.

Sustained translational repression by eIF2α-P mediates prion neurodegeneration.

Moreno JA, Radford H, Peretti D, Steinert JR, Verity N, Martin MG, Halliday M, Morgan J, Dinsdale D, Ortori CA, Barrett DA, Tsaytler P, Bertolotti A, Willis AE, Bushell M, Mallucci GR.

Nature. 2012 May 6;485(7399):507-11. doi: 10.1038/nature11058.

Relative expression of TAp73 and ΔNp73 isoforms.

Conforti F, Yang AL, Agostini M, Rufini A, Tucci P, Nicklison-Chirou MV, Grespi F, Velletri T, Knight RA, Melino G, Sayan BS.

Aging (Albany NY). 2012 Mar;4(3):202-5.

Resuscitating supplementary information: is the solution a two-for-one offer?

Knight RA, Melino G.

Cell Death Differ. 2012 Feb;19(2):185. doi: 10.1038/cdd.2011.177. No abstract available.

Switching from aerobic glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL.

Robinson GL, Dinsdale D, Macfarlane M, Cain K.

Oncogene. 2012 Feb 6. doi: 10.1038/onc.2012.13.

Removal notice to “acute depletion of the prion protein may abrogate Aβ oligomer toxicity” [Toxicology 290 (2011) 124].

Radford HE, Verity NC, Martin MG, Mallucci GR.

Toxicology. 2012 Dec 16;302(2-3):320. No abstract available.

Rescuing neurons in prion disease.

Verity NC, Mallucci GR.

Biochem J. 2011 Jan 1;433(1):19-29. Review.

The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity.

Malatesta M, Peschiaroli A, Memmi EM, Zhang J, Antonov A, Green DR, Barlev NA, Garabadgiu AV, Zhou P, Melino G, Bernassola F.

Oncogene. 2012 Oct 22. doi: 10.1038/onc.2012.463. [Epub ahead of print]

MicroRNA-203 contributes to skin re-epithelialization.

Viticchiè G, Lena AM, Cianfarani F, Odorisio T, Annicchiarico-Petruzzelli M, Melino G, Candi E.

Cell Death Dis. 2012 Nov 29;3:e435. doi: 10.1038/cddis.2012.174.

The "Sharp" blade against HIF-mediated metastasis.

Amelio I, Melino G.

Cell Cycle. 2012 Dec 15;11(24):4530-5. doi: 10.4161/cc.22820. Epub 2012 Nov 27.

NRF2 and p53: Januses in cancer?

Rotblat B, Melino G, Knight RA.

Oncotarget. 2012 Nov;3(11):1272-83.

p63 the guardian of human reproduction.

Amelio I, Grespi F, Annicchiarico-Petruzzelli M, Melino G.

Cell Cycle. 2012 Dec 15;11(24):4545-51. doi: 10.4161/cc.22819. Epub 2012 Nov 19.

Tissue-specific expression of p73 C-terminal isoforms in mice.

Grespi F, Amelio I, Tucci P, Annicchiarico-Petruzzelli M, Melino G.

Cell Cycle. 2012 Dec 1;11(23):4474-83. doi: 10.4161/cc.22787. Epub 2012 Nov 16.

PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21(WAF1) and p63.

Conforti F, Li Yang A, Cristina Piro M, Mellone M, Terrinoni A, Candi E, Tucci P, Thomas GJ, Knight RA, Melino G, Sayan BS.

Oncogene. 2012 Nov 5. doi: 10.1038/onc.2012.497. [Epub ahead of print]

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer.

Tucci P, Agostini M, Grespi F, Markert EK, Terrinoni A, Vousden KH, Muller PA, Dötsch V, Kehrloesser S, Sayan BS, Giaccone G, Lowe SW, Takahashi N, Vandenabeele P, Knight RA, Levine AJ, Melino G.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15312-7. Epub 2012 Sep 4.

Relative expression of TAp73 and ΔNp73 isoforms.

Conforti F, Yang AL, Agostini M, Rufini A, Tucci P, Nicklison-Chirou MV, Grespi F, Velletri T, Knight RA, Melino G, Sayan BS.

Aging (Albany NY). 2012 Mar;4(3):202-5.

Resuscitating supplementary information: is the solution a two-for-one offer?

Knight RA, Melino G.

Cell Death Differ. 2012 Feb;19(2):185. doi: 10.1038/cdd.2011.177. No abstract available.

microRNA-34a regulates neurite outgrowth, spinal morphology, and function.

Agostini M, Tucci P, Steinert JR, Shalom-Feuerstein R, Rouleau M, Aberdam D, Forsythe ID, Young KW, Ventura A, Concepcion CP, Han YC, Candi E, Knight RA, Mak TW, Melino G.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21099-104. doi: 10.1073/pnas.1112063108. Epub 2011 Dec 12.

Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor.

Chen YJ, Oldfield S, Butcher AJ, Tobin AB, Saxena K, Gurevich VV, Benovic JL, Henderson G, Kelly E.

J Neurochem. 2013 Jan;124(2):189-99. doi: 10.1111/jnc.12071. Epub 2012 Nov 30.

A unique protein phosphatase with kelch-like domains (PPKL) in Plasmodium modulates ookinete differentiation, motility and invasion.

Guttery DS, Poulin B, Ferguson DJ, Szöőr B, Wickstead B, Carroll PL, Ramakrishnan C, Brady D, Patzewitz EM, Straschil U, Solyakov L, Green JL, Sinden RE, Tobin AB, Holder AA, Tewari R.

PLoS Pathog. 2012 Sep;8(9):e1002948. doi: 10.1371/journal.ppat.1002948. Epub 2012 Sep 20.

Stimulus bias provides evidence for conformational constraints in the structure of a G protein-coupled receptor.

Gregory KJ, Sexton PM, Tobin AB, Christopoulos A.

J Biol Chem. 2012 Oct 26;287(44):37066-77. doi: 10.1074/jbc.M112.408534. Epub 2012 Sep 10.

An evolutionary perspective on the kinome of malaria parasites.

Talevich E, Tobin AB, Kannan N, Doerig C.

Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19;367(1602):2607-18. doi: 10.1098/rstb.2012.0014. Review.

Insights into the Plasmodium falciparum schizont phospho-proteome.

Lasonder E, Treeck M, Alam M, Tobin AB.

Microbes Infect. 2012 Aug;14(10):811-9. doi: 10.1016/j.micinf.2012.04.008. Epub 2012 May 5. Review.

Influence of the accessory protein SET on M3 muscarinic receptor phosphorylation and G protein coupling.

Simon V, Oner SS, Cohen-Tannoudji J, Tobin AB, Lanier SM.

Mol Pharmacol. 2012 Jul;82(1):17-26. doi: 10.1124/mol.111.075523. Epub 2012 Mar 30.

A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development.

Guttery DS, Ferguson DJ, Poulin B, Xu Z, Straschil U, Klop O, Solyakov L, Sandrini SM, Brady D, Nieduszynski CA, Janse CJ, Holder AA, Tobin AB, Tewari R.

PLoS Pathog. 2012 Feb;8(2):e1002554. doi: 10.1371/journal.ppat.1002554. Epub 2012 Feb 23. Erratum in: PLoS Pathog. 2012 Mar;8(3). doi: 10.1371/annotation/ef70d427-0816-4a63-aeaf-874b734793b0.

Physiological role of G-protein coupled receptor phosphorylation.

Butcher AJ, Kong KC, Prihandoko R, Tobin AB.

Handb Exp Pharmacol. 2012;(208):79-94. doi: 10.1007/978-3-642-23274-9_5. Review.

Spatiotemporal and functional characterisation of the Plasmodium falciparum cGMP-dependent protein kinase.

Hopp CS, Flueck C, Solyakov L, Tobin A, Baker DA.

PLoS One. 2012;7(11):e48206. doi: 10.1371/journal.pone.0048206. Epub 2012 Nov 5. 

2011

NOTE:

the list is alphabetical by surname of group leader at MRC Toxicology Unit;
author is in bold for each MRC Unit group leader;
author is underlined if another group leader in MRC Unit (and so duplication of paper in this list).

Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes.
Ferland-McCollough D, Fernandez-Twinn DS, Cannell IG, David H, Warner M, Vaag AA, Bork-Jensen J, Brøns C, Gant TW, Willis AE, Siddle K, Bushell M, Ozanne SE.
Cell Death Differ. 2012 Jan 6.

The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis.

Kress TR, Cannell IG, Brenkman AB, Samans B, Gaestel M, Roepman P, Burgering BM, Bushell M, Rosenwald A, Eilers M.

Mol Cell. 2011 Feb 18;41(4):445-57.

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms.
Feoktistova M, Geserick P, Kellert B, Dimitrova DP, Langlais C, Hupe M, Cain K, MacFarlane M, Häcker G, Leverkus M.
Mol Cell. 2011 Aug 5;43(3):449-63.
 
The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs.

Tenev T, Bianchi K, Darding M, Broemer M, Langlais C, Wallberg F, Zachariou A, Lopez J, MacFarlane M, Cain K, Meier P.

Mol Cell. 2011 Aug 5;43(3):432-48. Epub 2011 Jul 7. Erratum in: Mol Cell. 2011 Aug 19;43(4):689.

Early failure of N-methyl-D-aspartate receptors and deficient spine formation induced by reduction of regulatory heme in neurons.

Chernova T, Steinert JR, Richards P, Mistry R, Challiss RA, Jukes-Jones R, Cain K, Smith AG, Forsythe ID.

Mol Pharmacol. 2011 May;79(5):844-54. Epub 2011 Feb 15.

Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease.

Richards P, Didszun C, Campesan S, Simpson A, Horley B, Young KW, Glynn P, Cain K, Kyriacou CP, Giorgini F, Nicotera P.

Cell Death Differ. 2011 Feb;18(2):191-200. Epub 2010 Nov 19. Erratum in: Cell Death Differ. 2011 May;18(5):914.

BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation.

Vogler M, Hamali HA, Sun XM, Bampton ET, Dinsdale D, Snowden RT, Dyer MJ, Goodall AH, Cohen GM.

Blood. 2011 Jun 30;117(26):7145-54. Epub 2011 May 11.

The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein.

Vogler M, Dickens D, Dyer MJ, Owen A, Pirmohamed M, Cohen GM.

Biochem Biophys Res Commun. 2011 May 6;408(2):344-9. Epub 2011 Apr 13.

BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation.

Vogler M, Hamali HA, Sun XM, Bampton ET, Dinsdale D, Snowden RT, Dyer MJ, Goodall AH, Cohen GM.

Blood. 2011 Jun 30;117(26):7145-54. Epub 2011 May 11.

Lung exposure to nanoparticles modulates an asthmatic response in a mouse model.

Hussain S, Vanoirbeek JA, Luyts K, De Vooght V, Verbeken E, Thomassen LC, Martens JA, Dinsdale D, Boland S, Marano F, Nemery B, Hoet PH.

Eur Respir J. 2011 Feb;37(2):299-309. Epub 2010 Jun 7.        

MicroRNA expression profiling in patients with lamin A/C-associated muscular dystrophy.

Sylvius N, Bonne G, Straatman K, Reddy T, Gant TW, Shackleton S.

FASEB J. 2011 Sep 28. [Epub ahead of print]

Skills and training for the 21st century chemical toxicologist.

Gant TW.

Chem Res Toxicol. 2011 Jul 18;24(7):985-7. No abstract available.

Rescuing neurons in prion disease.

Verity NC, Mallucci GR.

Biochem J. 2011 Jan 1;433(1):19-29. Review.

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms.

Feoktistova M, Geserick P, Kellert B, Dimitrova DP, Langlais C, Hupe M, Cain K, MacFarlane M, Häcker G, Leverkus M.

Mol Cell. 2011 Aug 5;43(3):449-63. Epub 2011 Jul 7.

The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs.

Tenev T, Bianchi K, Darding M, Broemer M, Langlais C, Wallberg F, Zachariou A, Lopez J, MacFarlane M, Cain K, Meier P.

Mol Cell. 2011 Aug 5;43(3):432-48. Epub 2011 Jul 7. Erratum in: Mol Cell. 2011 Aug 19;43(4):689.

Disassembly of the JIP1/JNK molecular scaffold by caspase-3-mediated cleavage of JIP1 during apoptosis.

Vaishnav M, MacFarlane M, Dickens M.
Exp Cell Res. 2011 Apr 15;317(7):1028-39. Epub 2011 Jan 13.

Book Chapter:

“p53 in the Clinics” Chapter contribution: “The p53 family and stem cell biology” (2011)
Agostini M, Rufini A, Bampton ETW, Bernassola F, Melino G, Knight RA

microRNA-34a regulates neurite outgrowth, spinal morphology, and function.

Agostini M, Tucci P, Steinert JR, Shalom-Feuerstein R, Rouleau M, Aberdam D, Forsythe ID, Young KW, Ventura A, Concepcion CP, Han YC, Candi E, Knight RA, Mak TW, Melino G.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21099-104. Epub 2011 Dec 12.

Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets.

Agostini M, Tucci P, Killick R, Candi E, Sayan BS, Rivetti di Val Cervo P, Nicotera P, McKeon F, Knight RA, Mak TW, Melino G.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21093-8. Epub 2011 Dec 12.

Cell death pathology: The war against cancer.

Rufini A, Melino G.

Biochem Biophys Res Commun. 2011 Sep 28. [Epub ahead of print]

Cell death pathology: Perspective for human diseases.

Agostini M, Tucci P, Melino G.

Biochem Biophys Res Commun. 2011 Sep 21. [Epub ahead of print]

Cell death pathology: Cross-talk with autophagy and its clinical implications.

Amelio I, Melino G, Knight RA.

Biochem Biophys Res Commun. 2011 Oct 22;414(2):277-81. Epub 2011 Sep 22.

p63 in tooth development.

Rufini A, Barlattani A, Docimo R, Velletri T, Niklison-Chirou MV, Agostini M, Melino G.

Biochem Pharmacol. 2011 Nov 15;82(10):1256-61. Epub 2011 Jul 20.

p73 in Cancer.

Rufini A, Agostini M, Grespi F, Tomasini R, Sayan BS, Niklison-Chirou MV, Conforti F, Velletri T, Mastino A, Mak TW, Melino G, Knight RA.

Genes Cancer. 2011 Apr;2(4):491-502.

p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53.

Melino G.

Cell Death Differ. 2011 Sep;18(9):1487-99. doi: 10.1038/cdd.2011.81. Epub 2011 Jul 15.

P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism.

Al-Bahlani S, Fraser M, Wong AY, Sayan BS, Bergeron R, Melino G, Tsang BK.

Oncogene. 2011 Oct 13;30(41):4219-30. doi: 10.1038/onc.2011.134. Epub 2011 Apr 25.

miR-146a is modulated in human endothelial cell with aging.

Vasa-Nicotera M, Chen H, Tucci P, Yang AL, Saintigny G, Menghini R, Mahè C, Agostini M, Knight RA, Melino G, Federici M.

Atherosclerosis. 2011 Aug;217(2):326-30. Epub 2011 Apr 5.

p73: a multifunctional protein in neurobiology.

Killick R, Niklison-Chirou M, Tomasini R, Bano D, Rufini A, Grespi F, Velletri T, Tucci P, Sayan BS, Conforti F, Gallagher E, Nicotera P, Mak TW, Melino G, Knight RA, Agostini M.

Mol Neurobiol. 2011 Apr;43(2):139-46. Epub 2011 Mar 8. Review.

Ageing, neuronal connectivity and brain disorders: an unsolved ripple effect.

Bano D, Agostini M, Melino G, Nicotera P.

Mol Neurobiol. 2011 Apr;43(2):124-30. Epub 2011 Jan 15. Review.

Mitochondrial quality control and Parkinson's disease: a pathway unfolds.

de Castro IP, Martins LM, Loh SH.

Mol Neurobiol. 2011 Apr;43(2):80-6. Epub 2010 Dec 1. Review.

The regulatory role of heme in neurons.

Smith AG, Raven EL, Chernova T.

Metallomics. 2011 Oct 4;3(10):955-62. Epub 2011 Sep 16.

Early failure of N-methyl-D-aspartate receptors and deficient spine formation induced by reduction of regulatory heme in neurons.

Chernova T, Steinert JR, Richards P, Mistry R, Challiss RA, Jukes-Jones R, Cain K, Smith AG, Forsythe ID.

Mol Pharmacol. 2011 May;79(5):844-54. Epub 2011 Feb 15.

Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes.
Ferland-McCollough D, Fernandez-Twinn DS, Cannell IG, David H, Warner M, Vaag AA, Bork-Jensen J, Brøns C, Gant TW, Willis AE, Siddle K, Bushell M, Ozanne SE.
Cell Death Differ. 2012 Jan 6.

An integrative biological approach to the analysis of tissue culture data: application to the antitumour agent RHPS4.

Johnson LA, Byrne HM, Willis AE, Laughton CA.

Integr Biol (Camb). 2011 Aug;3(8):843-9. Epub 2011 Jul 19.

The biological and therapeutic relevance of mRNA translation in cancer.

Blagden SP, Willis AE.

Nat Rev Clin Oncol. 2011 May;8(5):280-91. Epub 2011 Mar 1. Review.

ATR (ataxia telangiectasia mutated- and Rad3-related kinase) is activated by mild hypothermia in mammalian cells and subsequently activates p53.

Roobol A, Roobol J, Carden MJ, Bastide A, Willis AE, Dunn WB, Goodacre R, Smales CM.

Biochem J. 2011 Apr 15;435(2):499-508.

2010

The involvement of microRNAs in Type 2 diabetes.

Ferland-McCollough D, Ozanne SE, Siddle K, Willis AE, Bushell M.

Biochem Soc Trans. 2010 Dec;38(6):1565-70. Review.

Translational regulation of gene expression during conditions of cell stress.

Spriggs KA, Bushell M, Willis AE.

Mol Cell. 2010 Oct 22;40(2):228-37. Review.

p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.

Cannell IG, Kong YW, Johnston SJ, Chen ML, Collins HM, Dobbyn HC, Elia A, Kress TR, Dickens M, Clemens MJ, Heery DM, Gaestel M, Eilers M, Willis AE, Bushell M.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5375-80. Epub 2010 Mar 8.

Regulation of Myc by miR-34c: A mechanism to prevent genomic instability?

Cannell IG, Bushell M.

Cell Cycle. 2010 Jul 15;9(14):2726-30. Epub 2010 Jul 27. Review.

Inhibition of hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis by DNA damage inducing agents.

Lou JJ, Chua YL, Chew EH, Gao J, Bushell M, Hagen T.

PLoS One. 2010 May 7;5(5):e10522.

LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.

James V, Zhang Y, Foxler DE, de Moor CH, Kong YW, Webb TM, Self TJ, Feng Y, Lagos D, Chu CY, Rana TM, Morley SJ, Longmore GD, Bushell M, Sharp TV.

Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12499-504. Epub 2010 Jun 28.

Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1.

Cobbold LC, Wilson LA, Sawicka K, King HA, Kondrashov AV, Spriggs KA, Bushell M, Willis AE.

Oncogene. 2010 May 13;29(19):2884-91. Epub 2010 Mar 1.

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species.

Capasso M, Bhamrah MK, Henley T, Boyd RS, Langlais C, Cain K, Dinsdale D, Pulford K, Khan M, Musset B, Cherny VV, Morgan D, Gascoyne RD, Vigorito E, DeCoursey TE, MacLennan IC, Dyer MJ.

Nat Immunol. 2010 Mar;11(3):265-72. Epub 2010 Feb 7.

Proteomic analysis of B-cell malignancies.

Boyd RS, Dyer MJ, Cain K.

J Proteomics. 2010 Sep 10;73(10):1804-22. Epub 2010 Mar 24. Review.

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species.

Capasso M, Bhamrah MK, Henley T, Boyd RS, Langlais C, Cain K, Dinsdale D, Pulford K, Khan M, Musset B, Cherny VV, Morgan D, Gascoyne RD, Vigorito E, DeCoursey TE, MacLennan IC, Dyer MJ.

Nat Immunol. 2010 Mar;11(3):265-72. Epub 2010 Feb 7.

Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration.

Bartesaghi S, Betts-Henderson J, Cain K, Dinsdale D, Zhou X, Karlsson A, Salomoni P, Nicotera P.

Hum Mol Genet. 2010 May 1;19(9):1669-77. Epub 2010 Feb 1.

TRAIL-Induced Apoptosis Is Preferentially Mediated via TRAIL Receptor 1 in Pancreatic Carcinoma Cells and Profoundly Enhanced by XIAP Inhibitors
Stadel D, Mohr A, Ref C, MacFarlane M, Zhou S, Humphreys R, Bachem M, Cohen G, Moller P, Zwacka RM, Debatin KM, Fulda S
Clin Cancer Res 16(23):5734-5749 01 Dec 2010

The in vitro cleavage of the hAtg proteins by cell death proteases.

Norman JM, Cohen GM, Bampton ET.

Autophagy. 2010 Nov;6(8):1042-56.

Diminished sensitivity of chronic lymphocytic leukemia cells to ABT-737 and ABT-263 due to albumin binding in blood.

Vogler M, Furdas SD, Jung M, Kuwana T, Dyer MJ, Cohen GM.

Clin Cancer Res. 2010 Aug 15;16(16):4217-25. Epub 2010 Jul 2.

Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells.

Baou M, Kohlhaas SL, Butterworth M, Vogler M, Dinsdale D, Walewska R, Majid A, Eldering E, Dyer MJ, Cohen GM.

Haematologica. 2010 Sep;95(9):1510-8. Epub 2010 Apr 7.

Acute hyperbilirubinaemia induces presynaptic neurodegeneration at a central glutamatergic synapse.

Haustein MD, Read DJ, Steinert JR, Pilati N, Dinsdale D, Forsythe ID.

J Physiol. 2010 Dec 1;588(Pt 23):4683-93. Epub 2010 Oct 11.

Different pathways lead to mitochondrial fragmentation during apoptotic and excitotoxic cell death in primary neurons.

Young KW, Piñon LG, Bampton ET, Nicotera P.

J Biochem Mol Toxicol. 2010 Sep-Oct;24(5):335-41.

Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells.

Baou M, Kohlhaas SL, Butterworth M, Vogler M, Dinsdale D, Walewska R, Majid A, Eldering E, Dyer MJ, Cohen GM.

Haematologica. 2010 Sep;95(9):1510-8. Epub 2010 Apr 7.

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species.

Capasso M, Bhamrah MK, Henley T, Boyd RS, Langlais C, Cain K, Dinsdale D, Pulford K, Khan M, Musset B, Cherny VV, Morgan D, Gascoyne RD, Vigorito E, DeCoursey TE, MacLennan IC, Dyer MJ.

Nat Immunol. 2010 Mar;11(3):265-72. Epub 2010 Feb 7.

Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration.

Bartesaghi S, Betts-Henderson J, Cain K, Dinsdale D, Zhou X, Karlsson A, Salomoni P, Nicotera P.

Hum Mol Genet. 2010 May 1;19(9):1669-77. Epub 2010 Feb 1.

Alteration of the nuclear pore complex in Ca(2+)-mediated cell death.

Bano D, Dinsdale D, Cabrera-Socorro A, Maida S, Lambacher N, McColl B, Ferrando-May E, Hengartner MO, Nicotera P.

Cell Death Differ. 2010 Jan;17(1):119-33. Epub.

Splenic infarction associated with rapidly progressive chronic lymphocytic leukemia with complex karyotype and ATM mutation.

Dyer MJ, Majid A, Walewska R, Gesk S, Harder L, Siebert R, Morgan B.

Leuk Res. 2011 May;35(5):e55-7. Epub 2010 Dec 24. No abstract available.

CD49d is an independent prognostic marker that is associated with CXCR4 expression in CLL.

Majid A, Lin TT, Best G, Fishlock K, Hewamana S, Pratt G, Yallop D, Buggins AG, Wagner S, Kennedy BJ, Miall F, Hills R, Devereux S, Oscier DG, Dyer MJ, Fegan C, Pepper C.

Leuk Res. 2011 Jun;35(6):750-6. Epub 2010 Nov 18.

Diminished sensitivity of chronic lymphocytic leukemia cells to ABT-737 and ABT-263 due to albumin binding in blood.

Vogler M, Furdas SD, Jung M, Kuwana T, Dyer MJ, Cohen GM.

Clin Cancer Res. 2010 Aug 15;16(16):4217-25. Epub 2010 Jul 2.

Deregulation of the telomerase reverse transcriptase (TERT) gene by chromosomal translocations in B-cell malignancies.

Nagel I, Szczepanowski M, Martín-Subero JI, Harder L, Akasaka T, Ammerpohl O, Callet-Bauchu E, Gascoyne RD, Gesk S, Horsman D, Klapper W, Majid A, Martinez-Climent JA, Stilgenbauer S, Tönnies H, Dyer MJ, Siebert R.

Blood. 2010 Aug 26;116(8):1317-20. Epub 2010 May 11.

Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol.

Cario G, Zimmermann M, Romey R, Gesk S, Vater I, Harbott J, Schrauder A, Moericke A, Izraeli S, Akasaka T, Dyer MJ, Siebert R, Schrappe M, Stanulla M.

Blood. 2010 Jul 1;115(26):5393-7. Epub 2010 Apr 8.

Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells.

Baou M, Kohlhaas SL, Butterworth M, Vogler M, Dinsdale D, Walewska R, Majid A, Eldering E, Dyer MJ, Cohen GM.

Haematologica. 2010 Sep;95(9):1510-8. Epub 2010 Apr 7.

Proteomic analysis of B-cell malignancies.

Boyd RS, Dyer MJ, Cain K.

J Proteomics. 2010 Sep 10;73(10):1804-22. Epub 2010 Mar 24. Review.

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species.

Capasso M, Bhamrah MK, Henley T, Boyd RS, Langlais C, Cain K, Dinsdale D, Pulford K, Khan M, Musset B, Cherny VV, Morgan D, Gascoyne RD, Vigorito E, DeCoursey TE, MacLennan IC, Dyer MJ.

Nat Immunol. 2010 Mar;11(3):265-72. Epub 2010 Feb 7.

Immunoglobulin heavy chain locus chromosomal translocations in B-cell precursor acute lymphoblastic leukemia: rare clinical curios or potent genetic drivers?

Dyer MJ, Akasaka T, Capasso M, Dusanjh P, Lee YF, Karran EL, Nagel I, Vater I, Cario G, Siebert R.

Blood. 2010 Feb 25;115(8):1490-9. Epub 2009 Dec 30. Review.

Identification of Thr29 as a critical phosphorylation site that activates the human proton channel Hvcn1 in leukocytes.

Musset B, Capasso M, Cherny VV, Morgan D, Bhamrah M, Dyer MJ, DeCoursey TE.

J Biol Chem. 2010 Feb 19;285(8):5117-21. Epub 2009 Dec 26.

Acute hyperbilirubinaemia induces presynaptic neurodegeneration at a central glutamatergic synapse.

Haustein MD, Read DJ, Steinert JR, Pilati N, Dinsdale D, Forsythe ID.

J Physiol. 2010 Dec 1;588(Pt 23):4683-93. Epub 2010 Oct 11.

Nitric oxide signaling in brain function, dysfunction, and dementia.

Steinert JR, Chernova T, Forsythe ID.

Neuroscientist. 2010 Aug;16(4):435-52. Review.

Lateral olivocochlear (LOC) neurons of the mouse LSO receive excitatory and inhibitory synaptic inputs with slower kinetics than LSO principal neurons.

Sterenborg JC, Pilati N, Sheridan CJ, Uchitel OD, Forsythe ID, Barnes-Davies M.

Hear Res. 2010 Dec 1;270(1-2):119-26. Epub 2010 Sep 8.

An introduction to Peter Stanfield's festschrift.

Forsythe ID, Grubb BD, Dale N.

J Physiol. 2010 Sep 1;588(Pt 17):3139-40. No abstract available.

Presynaptic and postsynaptic origin of multicomponent extracellular waveforms at the endbulb of Held-spherical bushy cell synapse.

Typlt M, Haustein MD, Dietz B, Steinert JR, Witte M, Englitz B, Milenkovic I, Kopp-Scheinpflug C, Forsythe ID, Rübsamen R.

Eur J Neurosci. 2010 May;31(9):1574-81.

Going native: voltage-gated potassium channels controlling neuronal excitability.

Johnston J, Forsythe ID, Kopp-Scheinpflug C.

J Physiol. 2010 Sep 1;588(Pt 17):3187-200. Epub 2010 Jun 2. Review.

Gain of function in FHM-1 Ca(V)2.1 knock-in mice is related to the shape of the action potential.

Inchauspe CG, Urbano FJ, Di Guilmi MN, Forsythe ID, Ferrari MD, van den Maagdenberg AM, Uchitel OD.

J Neurophysiol. 2010 Jul;104(1):291-9. Epub 2010 May 19.

Kv1.3 is the exclusive voltage-gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count.

McCloskey C, Jones S, Amisten S, Snowden RT, Kaczmarek LK, Erlinge D, Goodall AH, Forsythe ID, Mahaut-Smith MP.

J Physiol. 2010 May 1;588(Pt 9):1399-406. Epub 2010 Mar 22.

Regulation of Kv channel expression and neuronal excitability in rat medial nucleus of the trapezoid body maintained in organotypic culture.

Tong H, Steinert JR, Robinson SW, Chernova T, Read DJ, Oliver DL, Forsythe ID.

J Physiol. 2010 May 1;588(Pt 9):1451-68. Epub 2010 Mar 8.

NMDAR-mediated EPSCs are maintained and accelerate in time course during maturation of mouse and rat auditory brainstem in vitro.

Steinert JR, Postlethwaite M, Jordan MD, Chernova T, Robinson SW, Forsythe ID.

J Physiol. 2010 Feb 1;588(Pt 3):447-63. Epub 2009 Dec 14.

Mevastatin accelerates loss of synaptic proteins and neurite degeneration in aging cortical neurons in a heme-independent manner.

Kannan M, Steinert JR, Forsythe ID, Smith AG, Chernova T.

Neurobiol Aging. 2010 Sep;31(9):1543-53. Epub 2008 Oct 31.

Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation.

Pointon AV, Walker TM, Phillips KM, Luo J, Riley J, Zhang SD, Parry JD, Lyon JJ, Marczylo EL, Gant TW.

PLoS One. 2010 Sep 15;5(9):e12733.

Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability.

Foster CT, Dovey OM, Lezina L, Luo JL, Gant TW, Barlev N, Bradley A, Cowley SM.

Mol Cell Biol. 2010 Oct;30(20):4851-63. Epub 2010 Aug 16.

Upregulation of nuclear-encoded mitochondrial LON protease in HAART-treated HIV-positive patients with lipodystrophy: implications for the pathogenesis of the disease.

Pinti M, Gibellini L, Guaraldi G, Orlando G, Gant TW, Morselli E, Nasi M, Salomoni P, Mussini C, Cossarizza A.

AIDS. 2010 Mar 27;24(6):841-50.

Defective TPA signalling compromises HaCat cells as a human in vitro skin carcinogenesis model.

Ridd K, Dhir S, Smith AG, Gant TW.

Toxicol In Vitro. 2010 Apr;24(3):910-5. Epub 2009 Nov 27.

Application of connectivity mapping in predictive toxicology based on gene-expression similarity.

Smalley JL, Gant TW, Zhang SD.

Toxicology. 2010 Feb 9;268(3):143-6. Epub 2009 Sep 27. Review.

TRAIL-induced apoptosis is preferentially mediated via TRAIL receptor 1 in pancreatic carcinoma cells and profoundly enhanced by XIAP inhibitors.

Stadel D, Mohr A, Ref C, MacFarlane M, Zhou S, Humphreys R, Bachem M, Cohen G, Möller P, Zwacka RM, Debatin KM, Fulda S.

Clin Cancer Res. 2010 Dec 1;16(23):5734-49. Epub 2010 Oct 12.

TRAIL-induced apoptosis is preferentially mediated via TRAIL receptor 1 in pancreatic carcinoma cells and profoundly enhanced by XIAP inhibitors

Stadel D, Macfarlane M, Zhou S, Humphreys R, Bachem M, Cohen G, Moeller P, Debatin KM, Fulda S

ONKOLOGIE  Volume: 33   Supplement: 6   Pages: 24-24   Published: OCT 2010

Development of a doxycyclinedependent caspase 3 death switch model to assess the immune response to rapid and synchronous tumour cell apoptosis in vivo

Melis M, Simpson K, Honeychurch J, Weldman A, MacFarlane M, Dive C, Illidge T

EJC SUPPLEMENTS  Volume: 8   Issue: 5   Pages: 101-102   Meeting Abstract: 397   Published: JUN 2010

Mitochondrial fragmentation and neuronal cell death in response to the Bcl-2/Bcl-x(L)/Bcl-w antagonist ABT-737.

Young KW, Piñón LG, Dhiraj D, Twiddy D, Macfarlane M, Hickman J, Nicotera P.

Neuropharmacology. 2010 Jun;58(8):1258-67. Epub 2010 Mar 20.

A TRAIL-R1-specific ligand in combination with doxorubicin selectively targets primary breast tumour cells for apoptosis

Twiddy D, Naik S, Mistry R, Edwards J, Walker RA, Cohen GM, MacFarlane M

BREAST CANCER RESEARCH  Volume: 12   Supplement: 1   Pages: S17-S18   Article Number: P58  

Book Chapter:
MacFarlane M (2010) ‘Death Receptors at the Molecular Level: Therapeutic Implications’ In: Encyclopedia of Life Sciences. John Wiley & Sons Ltd, Chichester. http://www.els.net

Dysfunction and recovery of synapses in prion disease: implications for neurodegeneration.

Moreno JA, Mallucci GR.

Biochem Soc Trans. 2010 Apr;38(2):482-7. Review.

The role of GPI-anchored PrP C in mediating the neurotoxic effect of scrapie prions in neurons.

Radford HE, Mallucci GR.

Curr Issues Mol Biol. 2010;12(2):119-27. Epub 2009 Sep 18. Review.

Drosophila happyhour modulates JNK-dependent apoptosis.

Lam D, Shah S, de Castro IP, Loh SH, Martins LM.

Cell Death Dis. 2010 Aug 19;1:e66.

Cancer and neurodegeneration: between the devil and the deep blue sea.

Plun-Favreau H, Lewis PA, Hardy J, Martins LM, Wood NW.

PLoS Genet. 2010 Dec 23;6(12):e1001257. Review.

PINK1 cleavage at position A103 by the mitochondrial protease PARL.

Deas E, Plun-Favreau H, Gandhi S, Desmond H, Kjaer S, Loh SH, Renton AE, Harvey RJ, Whitworth AJ, Martins LM, Abramov AY, Wood NW.

Hum Mol Genet. 2011 Mar 1;20(5):867-79. Epub 2010 Dec 6.

Mitochondrial quality control and neurological disease: an emerging connection.

de Castro IP, Martins LM, Tufi R.

Expert Rev Mol Med. 2010 Apr 19;12:e12. Review.

Policy and procedures on scientific misconduct.

Melino G.

Cell Death Differ. 2010 Dec;17(12):1805-6. No abstract available.

p73 regulates maintenance of neural stem cell.

Agostini M, Tucci P, Chen H, Knight RA, Bano D, Nicotera P, McKeon F, Melino G.

Biochem Biophys Res Commun. 2010 Dec 3;403(1):13-7. Epub 2010 Oct 25.

Skn-1a/Oct-11 and ΔNp63α exert antagonizing effects on human keratin expression.

Lena AM, Cipollone R, Amelio I, Catani MV, Ramadan S, Browne G, Melino G, Candi E.

Biochem Biophys Res Commun. 2010 Oct 29;401(4):568-73. Epub 2010 Oct 1.

Journal club. A cancer biologist weighs up p53, metabolism and cancer.

Melino G.

Nature. 2010 Aug 19;466(7309):905. No abstract available.

Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2.

Sayan BS, Yang AL, Conforti F, Tucci P, Piro MC, Browne GJ, Agostini M, Bernardini S, Knight RA, Mak TW, Melino G.

Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):12877-82. Epub 2010 Jul 6.

p73 and p63 regulate the expression of fibroblast growth factor receptor 3.

Sayan AE, D'Angelo B, Sayan BS, Tucci P, Cimini A, Cerù MP, Knight RA, Melino G.

Biochem Biophys Res Commun. 2010 Apr 9;394(3):824-8. Epub 2010 Mar 16.

miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro.

Chen H, Shalom-Feuerstein R, Riley J, Zhang SD, Tucci P, Agostini M, Aberdam D, Knight RA, Genchi G, Nicotera P, Melino G, Vasa-Nicotera M.

Biochem Biophys Res Commun. 2010 Apr 16;394(4):921-7. Epub 2010 Mar 15.

Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway.

Wilhelm MT, Rufini A, Wetzel MK, Tsuchihara K, Inoue S, Tomasini R, Itie-Youten A, Wakeham A, Arsenian-Henriksson M, Melino G, Kaplan DR, Miller FD, Mak TW.

Genes Dev. 2010 Mar 15;24(6):549-60. Epub 2010 Mar 1.

Induction of TAp63 by histone deacetylase inhibitors.

Sayan BS, Yang AL, Conforti F, Bernardini S, Tucci P, Vasa-Nicotera M, Knight RA, Melino G.

Biochem Biophys Res Commun. 2010 Jan 22;391(4):1748-51. Epub 2009 Dec 30.

Complex gene-chemical interactions: hepatic uroporphyria as a paradigm.

Smith AG, Elder GH.

Chem Res Toxicol. 2010 Apr 19;23(4):712-23. Review.

Defective TPA signalling compromises HaCat cells as a human in vitro skin carcinogenesis model.

Ridd K, Dhir S, Smith AG, Gant TW.

Toxicol In Vitro. 2010 Apr;24(3):910-5. Epub 2009 Nov 27.

Mevastatin accelerates loss of synaptic proteins and neurite degeneration in aging cortical neurons in a heme-independent manner.

Kannan M, Steinert JR, Forsythe ID, Smith AG, Chernova T.

Neurobiol Aging. 2010 Sep;31(9):1543-53. Epub 2008 Oct 31.

Translation deregulation in B-cell lymphomas.

Horvilleur E, Wilson LA, Willis AE.

Biochem Soc Trans. 2010 Dec;38(6):1593-7.

The role of IRES trans-acting factors in regulating translation initiation.

King HA, Cobbold LC, Willis AE.

Biochem Soc Trans. 2010 Dec;38(6):1581-6.

The involvement of microRNAs in Type 2 diabetes.

Ferland-McCollough D, Ozanne SE, Siddle K, Willis AE, Bushell M.

Biochem Soc Trans. 2010 Dec;38(6):1565-70. Review.

Translational regulation of gene expression during conditions of cell stress.

Spriggs KA, Bushell M, Willis AE.

Mol Cell. 2010 Oct 22;40(2):228-37. Review.

eIF4A inhibition allows translational regulation of mRNAs encoding proteins involved in Alzheimer's disease.

Bottley A, Phillips NM, Webb TE, Willis AE, Spriggs KA.

PLoS One. 2010 Sep 28;5(9). pii: e13030.

The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration.

Burrows C, Abd Latip N, Lam SJ, Carpenter L, Sawicka K, Tzolovsky G, Gabra H, Bushell M, Glover DM, Willis AE, Blagden SP.

Nucleic Acids Res. 2010 Sep;38(16):5542-53. Epub 2010 Apr 29.

p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.

Cannell IG, Kong YW, Johnston SJ, Chen ML, Collins HM, Dobbyn HC, Elia A, Kress TR, Dickens M, Clemens MJ, Heery DM, Gaestel M, Eilers M, Willis AE, Bushell M.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5375-80. Epub 2010 Mar 8.

Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1.

Cobbold LC, Wilson LA, Sawicka K, King HA, Kondrashov AV, Spriggs KA, Bushell M, Willis AE.

Oncogene. 2010 May 13;29(19):2884-91. Epub 2010 Mar 1.

Dysregulation of protein synthesis and disease.

Le Quesne JP, Spriggs KA, Bushell M, Willis AE.

J Pathol. 2010 Jan;220(2):140-51. Review.