Imaging and Pathology

Dr David Dinsdale FRCPath

Head of the Imaging & Pathology Group

MRC Toxicology Unit
Hodgkin Building
PO Box 138
University of Leicester
Lancaster Road, Leicester
LE1 9HN, UK

Tel: +44 (0)116 252 5615 (Lab: 0116 252 3042)
Email: Send Email

Qualifications and Personal History

Senior Investigator Scientist MRC Toxicology Unit  2003- present.
Non-clinical Scientist, MRC Toxicology Unit  1979-2003
Scientific Officer, Rowett Research Institute 1972-79
DPhil (Intracellular digestion), University of Ulster 1972
BSc (Zoology), University of Reading  1969

Recent Selected Publications

Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes.

Tucci P, Porta G, Agostini M, Dinsdale D, Iavicoli I, Cain K, Finazzi-Agró A, Melino G, Willis A.

Cell Death Dis. 2013 Mar 21;4:e549. doi: 10.1038/cddis.2013.76.

Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.

Varadarajan S, Tanaka K, Smalley JL, Bampton ET, Pellecchia M, Dinsdale D, Willars GB, Cohen GM.

PLoS One. 2013;8(2):e56603. doi: 10.1371/journal.pone.0056603. Epub 2013 Feb 15.

miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration.

Amelio I, Lena AM, Viticchiè G, Shalom-Feuerstein R, Terrinoni A, Dinsdale D, Russo G, Fortunato C, Bonanno E, Spagnoli LG, Aberdam D, Knight RA, Candi E, Melino G.

J Cell Biol. 2012 Oct 15;199(2):347-63. doi: 10.1083/jcb.201203134.

A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum.

Varadarajan S, Bampton ET, Smalley JL, Tanaka K, Caves RE, Butterworth M, Wei J, Pellecchia M, Mitcheson J, Gant TW, Dinsdale D, Cohen GM.

Cell Death Differ. 2012 Dec;19(12):1896-907. doi: 10.1038/cdd.2012.108. Epub 2012 Sep 7.

Sustained translational repression by eIF2α-P mediates prion neurodegeneration.

Moreno JA, Radford H, Peretti D, Steinert JR, Verity N, Martin MG, Halliday M, Morgan J, Dinsdale D, Ortori CA, Barrett DA, Tsaytler P, Bertolotti A, Willis AE, Bushell M, Mallucci GR.

Nature. 2012 May 6;485(7399):507-11. doi: 10.1038/nature11058.

Switching from aerobic glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL.

Robinson GL, Dinsdale D, Macfarlane M, Cain K.

Oncogene. 2012 Nov 29;31(48):4996-5006. doi: 10.1038/onc.2012.13. Epub 2012 Feb 6.

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.

Pimenta de Castro I, Costa AC, Lam D, Tufi R, Fedele V, Moisoi N, Dinsdale D, Deas E, Loh SH, Martins LM.

Cell Death Differ. 2012 Aug;19(8):1308-16. doi: 10.1038/cdd.2012.5. Epub 2012 Feb 3.

BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation.

Vogler M, Hamali HA, Sun XM, Bampton ET, Dinsdale D, Snowden RT, Dyer MJ, Goodall AH, Cohen GM.

Blood. 2011 Jun 30;117(26):7145-54. doi: 10.1182/blood-2011-03-344812. Epub 2011 May 11.

Acute hyperbilirubinaemia induces presynaptic neurodegeneration at a central glutamatergic synapse.

Haustein MD, Read DJ, Steinert JR, Pilati N, Dinsdale D, Forsythe ID.

J Physiol. 2010 Dec 1;588(Pt 23):4683-93. doi: 10.1113/jphysiol.2010.199778. Epub 2010 Oct 11.

Lung exposure to nanoparticles modulates an asthmatic response in a mouse model.

Hussain S, Vanoirbeek JA, Luyts K, De Vooght V, Verbeken E, Thomassen LC, Martens JA, Dinsdale D, Boland S, Marano F, Nemery B, Hoet PH.

Eur Respir J. 2011 Feb;37(2):299-309. doi: 10.1183/09031936.00168509. Epub 2010 Jun 7.

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species.

Capasso M, Bhamrah MK, Henley T, Boyd RS, Langlais C, Cain K, Dinsdale D, Pulford K, Khan M, Musset B, Cherny VV, Morgan D, Gascoyne RD, Vigorito E, DeCoursey TE, MacLennan IC, Dyer MJ.

Nat Immunol. 2010 Mar;11(3):265-72. doi: 10.1038/ni.1843. Epub 2010 Feb 7.

Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux.

Rossi M, Munarriz ER, Bartesaghi S, Milanese M, Dinsdale D, Guerra-Martin MA, Bampton ET, Glynn P, Bonanno G, Knight RA, Nicotera P, Melino G.

J Cell Sci. 2009 Sep 15;122(Pt 18):3330-9. doi: 10.1242/jcs.048181. Epub 2009 Aug 25.

Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells.

Bellodi C, Lidonnici MR, Hamilton A, Helgason GV, Soliera AR, Ronchetti M, Galavotti S, Young KW, Selmi T, Yacobi R, Van Etten RA, Donato N, Hunter A, Dinsdale D, Tirrò E, Vigneri P, Nicotera P, Dyer MJ, Holyoake T, Salomoni P, Calabretta B.

J Clin Invest. 2009 May;119(5):1109-23. doi: 10.1172/JCI35660. Epub 2009 Apr 13.

A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells.

Vogler M, Dinsdale D, Sun XM, Young KW, Butterworth M, Nicotera P, Dyer MJ, Cohen GM.

Cell Death Differ. 2008 May;15(5):820-30. doi: 10.1038/cdd.2008.25. Epub 2008 Feb 29.

FLASH is an essential component of Cajal bodies.

Barcaroli D, Dinsdale D, Neale MH, Bongiorno-Borbone L, Ranalli M, Munarriz E, Sayan AE, McWilliam JM, Smith TM, Fava E, Knight RA, Melino G, De Laurenzi V.

Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14802-7. Epub 2006 Sep 26.

Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice.

Candi E, Rufini A, Terrinoni A, Dinsdale D, Ranalli M, Paradisi A, De Laurenzi V, Spagnoli LG, Catani MV, Ramadan S, Knight RA, Melino G.

Cell Death Differ. 2006 Jun;13(6):1037-47.

Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis.

Berliocchi L, Fava E, Leist M, Horvat V, Dinsdale D, Read D, Nicotera P.

J Cell Biol. 2005 Feb 14;168(4):607-18.

Intermediate filaments control the intracellular distribution of caspases during apoptosis.

Dinsdale D, Lee JC, Dewson G, Cohen GM, Peter ME.

Am J Pathol. 2004 Feb;164(2):395-407.