Protein Profiling Group

Professor Kelvin Cain

Group Leader

MRC Toxicology Unit
Hodgkin Building
PO Box 138
University of Leicester
Lancaster Road, Leicester
LE1 9HN, UK

Tel: +44 (0)116 252 5547/5573 (lab)
Email: Send Email

Qualifications and Personal History

2002-Present Group Leader
1996- Band 2 Scientist
1993-1996 Senior Scientist
1984-1993 Tenured Scientist
1977-1984 MRC Toxicology Unit, Scientist
1976 PhD Molecular Sciences, University of Warwick
1972 BsC Hons Pharmacology

Selected Publications

Cain, K., Bratton, S.B., and Cohen, G.M. (2002). The Apaf-1 apoptosome: a large caspase-activating complex. Biochimie 84, 203-214.

Twiddy D, et al. (2004) Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex. J Biol.Chem. 279(19):19665-19682.

Twiddy D, Cohen GM, Macfarlane M, & Cain K (2006) Caspase-7 is directly activated by the approximately 700-kDa apoptosome complex and is released as a stable XIAP-caspase-7 approximately 200-kDa complex. J Biol Chem 281(7):3876-3888.

Boyd, R.S., Jukes-Jones, R., Walewska, R., Brown, D., Dyer, M.J., and Cain, K. (2009). Protein profiling of plasma membranes defines aberrant signaling pathways in mantle cell lymphoma. Mol Cell Proteomics 8, 1501-1515.

Hughes, M.A., Harper, N., Butterworth, M., Cain, K., Cohen, G.M., and MacFarlane, M. (2009). Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival. MolCell 35, 265-279.

Hughes MA, et al. (2009) Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival. Mol.Cell 35(3):265-279.

Capasso, M., Bhamrah, M.K., Henley, T., Boyd, R.S., Langlais, C., Cain, K., Dinsdale, D., Pulford, K., Khan, M., Musset, B., et al. (2010). HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species. NatImmunol 11, 265-272.

Boyd RS, Dyer MJ, & Cain K (2010) Proteomic analysis of B-cell malignancies. J Proteomics 73(10):1804-1822.

Bartesaghi, S., Betts-Henderson, J., Cain, K., Dinsdale, D., Zhou, X., Karlsson, A., Salomoni, P., and Nicotera, P. (2010). Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration. HumMolGenet 19, 1669-1677.

Richards, P., Didszun, C., Campesan, S., Simpson, A., Horley, B., Young, K.W., Glynn, P., Cain, K., Kyriacou, C.P., Giorgini, F., et al. (2011). Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease. Cell Death Differ 18, 191-200.

Feoktistova, M., Geserick, P., Kellert, B., Dimitrova, D.P., Langlais, C., Hupe, M., Cain, K., Macfarlane, M., Hacker, G., and Leverkus, M. (2011). cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms. Mol Cell 43, 449-463.

Tenev, T., Bianchi, K., Darding, M., Broemer, M., Langlais, C., Wallberg, F., Zachariou, A., Lopez, J., Macfarlane, M., Cain, K. and Meier, P. (2011). The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs. Mol Cell 43, 432-448.

Robinson, G.L., Dinsdale, D., Macfarlane, M., and Cain, K. (2012). Switching from aerobic     glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL. Oncogene. 2012, 1-12 online pub 6^th Feb